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What are healthy Estradiol numbers?

Updated

Healthy estradiol levels vary significantly based on factors such as age, sex, and physiological conditions. Here is a summary of the reference ranges for estradiol levels in different populations:

Estradiol Levels in Women:

1. Premenopausal Women

Estradiol levels fluctuate throughout the menstrual cycle:

  • Follicular Phase (beginning of the cycle): 20-150 pg/mL
  • Ovulation (mid-cycle): 150-450 pg/mL
  • Luteal Phase (after ovulation): 100-250 pg/mL

2. Postmenopausal Women

Typical Range: Less than 20-30 pg/mL

Estradiol Levels in Men:

Typical Range: 10-40 pg/mL

Estradiol Levels During Pregnancy:

Estradiol levels increase significantly during pregnancy:

  • First Trimester: 188-2497 pg/mL
  • Second Trimester: 1278-7192 pg/mL
  • Third Trimester: 6137-3460 pg/mL

Athletes:

  • Physically active male athletes show a chronic increase in testosterone with concurrent physiological increases in estradiol.
  • Analytical Methods and Variability
  • The variability in estradiol levels can be attributed to differences in analytical methods. Highly sensitive and specific methods, such as LC-MS/MS, are recommended for accurate measurement.

Further Reading:

  1. Estradiol blood test Information | Mount Sinai - New York. (n.d.). Mount Sinai Health System. https://www.mountsinai.org/health-library/tests/estradiol-blood-test
  2. Normal Estradiol Levels by Age: Understanding Hormonal Balance. (2023, August 20). https://wowrxpharmacy.com/blog/womens-health/normal-estradiol-levels-by-age/#:~:text=Normal%20Estradiol%20levels%20in%20an%20adult%20male%20are
  3. ‌Chen, T., Wu, F., Wang, X., Ma, G., Xuan, X., Tang, R., Ding, S., & Lu, J. (2020). Different levels of estradiol are correlated with sexual dysfunction in adult men. Scientific Reports, 10(1), 12660. https://doi.org/10.1038/s41598-020-69712-6
  4. Cadegiani, F., Abrao, T. P. C., da Silva, P. L. H., & Kater, C. E. (2020). MON-LB305 The “Normal” Hormonal Levels in Athletes: Should Reference Ranges Be Adapted for the Physically Active Population?. Journal of the Endocrine Society, 4(Supplement_1). https://doi.org/10.1210/jendso/bvaa046.2321