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Can Kyzatrex testosterone therapy treat erectile dysfunction (ED)?

Updated

Kyzatrex testosterone therapy can be used to treat erectile dysfunction (ED), particularly in men with low testosterone levels (hypogonadism). Studies show that testosterone therapy can significantly improve ED symptoms in hypogonadal men, with 91.9% of young men with organic ED reporting improvement after therapy. Combining testosterone therapy with PDE5 inhibitors, like sildenafil, has proven effective for men who do not respond to PDE5 inhibitors alone, restoring erectile function in 70% of diabetic participants. Long-term testosterone therapy has shown benefits in improving erectile function in men with functional hypogonadism and obesity, with significant improvements noted over up to 13 years. Testosterone therapy has also been effective in men with venous leakage, with some reporting significant improvement within 12-20 weeks of treatment. Additionally, in men with type 2 diabetes and hypogonadism, long-acting testosterone undecanoate improved sexual function and quality of life, including better IIEF scores. Regular monitoring and a tailored approach by healthcare providers are essential to maximize benefits and manage potential risks.

Further Reading:

  1. Song, J., G Saffati, Naeem, T., Biles, B., Pierce, H., Lipshultz, L., & Khera, M. (2024). (160) Improving Symptoms in Young Men with Erectile Dysfunction: Testosterone Therapy with or Without PDE5 Inhibitors. the Journal of Sexual Medicine, 21(Supplement_1). https://doi.org/10.1093/jsxmed/qdae001.151
  2. Kalinchenko, S. Y., Kozlov, G. I., Gontcharov, N. P., & Katsiya, G. V. (2003). Oral testosterone undecanoate reverses erectile dysfunction associated with diabetes mellitus in patients failing on sildenafil citrate therapy alone. The Aging Male: The Official Journal of the International Society for the Study of the Aging Male, 6(2), 94–99. https://pubmed.ncbi.nlm.nih.gov/12898793/
  3. Yassin, A., Saad, F., & Traish, A. M. (2006). Testosterone Undecanoate Restores Erectile Function in a Subset of Patients with Venous Leakage: A Series of Case Reports. The Journal of Sexual Medicine, 3(4), 727–735. https://doi.org/10.1111/j.1743-6109.2006.00267.x
  4. Hackett, G., Cole, N., Bhartia, M., Kennedy, D., Raju, J., & Wilkinson, P. (2013). Testosterone Replacement Therapy with Long‒Acting Testosterone Undecanoate Improves Sexual Function and Quality‒of‒Life Parameters vs. Placebo in a Population of Men with Type 2 Diabetes. The Journal of Sexual Medicine, 10(6), 1612–1627. https://doi.org/10.1111/jsm.12146
  5. Saad, F., Haider, K. S., Haider, A., Doros, G., & A Traish. (2023). (396) Effects of Long-term Testosterone Therapy in Men with Functional Hypogonadism and Obesity on Weight, Waist Circumference, and Erectile Function – Results from a Registry Study. the Journal of Sexual Medicine, 20(Supplement_1). https://doi.org/10.1093/jsxmed/qdad060.370