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How does Kyzatrex work?

Updated

Kyzatrex™ is an oral testosterone replacement therapy. It is absorbed through the lymphatic system, avoiding the liver's initial breakdown, which helps maintain stable testosterone levels. Once in the body, Kyzatrex™ converts to active testosterone, which binds to receptors in muscles, bones, and other tissues, improving energy, sex drive, and muscle mass. Testosterone works by binding to androgen receptors, which then regulate genes involved in male health and development. This process supports muscle growth, bone density, and sexual function, making Kyzatrex™ effective in treating low testosterone levels.

Further Reading:

  1. Kim, Y., Lee, D., Jo, H., Go, C., Yang, J., Kang, D., & Kang, J. S. (2021). GV1001 interacts with androgen receptor to inhibit prostate cell proliferation in benign prostatic hyperplasia by regulating expression of molecules related to epithelial-mesenchymal transition. Aging, 13(3), 3202–3217. https://doi.org/10.18632/aging.202242 
  2. Ayoub, R., Page, S. T., Swerdloff, R. S., Liu, P. Y., Amory, J. K., Leung, A., Hull, L., Blithe, D., Christy, A., Chao, J. H., Bremner, W. J., & Wang, C. (2016). Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive. Andrology, 5(2), 278–285. https://doi.org/10.1111/andr.12303
  3. Thomas, P. (2019). Membrane Androgen Receptors Unrelated to Nuclear Steroid Receptors. Endocrinology, 160(4), 772–781. https://doi.org/10.1210/en.2018-00987
  4. White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KyzatrexTM on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297
  5. A. Michael Lincoff, Bhasin, S., Panagiotis Flevaris, Mitchell, L. M., Shehzad Basaria, Boden, W. E., Cunningham, G. R., Granger, C. B., Khera, M., Thompson, I. M., Wang, Q., Wolski, K., Davey, D., Vidyasagar, Kalahasti, Khan, N., Miller, M. G., Snabes, M. C., Chan, A., Dubcenco, E., & Li, X. (2023). Cardiovascular Safety of Testosterone-Replacement Therapy. https://doi.org/10.1056/nejmoa2215025
  6. Why Kyzatrex | Safe to Use, Easy to Take, and Up to 96% Effective. (n.d.). Kyzatrex. Retrieved May 17, 2024, from https://www.kyzatrex.com/why-kyzatrex/