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How does Kyzatrex compare to other testosterone replacement therapies?

Updated

Kyzatrex™ (oral testosterone) can slightly raise blood pressure, especially in people on blood pressure medication, with little effect on heart rate. Intranasal testosterone gel (Natesto) has minimal impact on blood tests and low risk of increasing red blood cell count. Intramuscular testosterone cypionate raises red blood cell levels more significantly, which can be risky. Transdermal testosterone gel and long-acting intramuscular testosterone don't significantly increase heart problems. Overall, Kyzatrex™ works well but needs blood pressure monitoring, especially for those with high blood pressure.

Further Reading:

  1. White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KyzatrexTM on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297
  2. Rivero, M.-J., Ory, J., Diaz, P., Nannan Thirumavalavan, Han, S., Reis, I. M., & Ramasamy, R. (2023). Comparison of Hematocrit Change in Testosterone-deficient Men Treated with Intranasal Testosterone Gel vs Intramuscular Testosterone Cypionate: A Randomized Clinical Trial. The Journal of Urology, 210(1), 162–170. https://doi.org/10.1097/ju.0000000000003487
  3. A. Michael Lincoff, Bhasin, S., Panagiotis Flevaris, Mitchell, L. M., Shehzad Basaria, Boden, W. E., Cunningham, G. R., Granger, C. B., Khera, M., Thompson, I. M., Wang, Q., Wolski, K., Davey, D., Vidyasagar Kalahasti, Khan, N., Miller, M. G., Snabes, M. C., Chan, A., Dubcenco, E., & Li, X. (2023). Cardiovascular Safety of Testosterone-Replacement Therapy. https://doi.org/10.1056/nejmoa2215025
  4. Kovac, J. R., Rajanahally, S., Smith, R. P., Coward, R. M., Lamb, D. J., & Lipshultz, L. I. (2014). Patient Satisfaction with Testosterone Replacement Therapies: The Reasons Behind the Choices. The Journal of Sexual Medicine, 11(2), 553–562. https://doi.org/10.1111/jsm.12369
  5. Zitzmann, M., Cremers, J. F., Krallmann, C., & Kliesch, S. (2022). The HEAT-Registry (HEmatopoietic Affection by Testosterone): comparison of a transdermal gel vs long-acting intramuscular testosterone undecanoate in hypogonadal men. The Aging Male, 25(1), 134–144. https://doi.org/10.1080/13685538.2022.2063830
  6. Best, J., Gonzalez, D., Masterson, T., Blachman-Braun, R., Pai, R., & Ramasamy, R. (2020). A cross-sectional comparison of secondary polycythemia in testosterone-deficient men treated with nasal testosterone gel vs. intramuscular testosterone cypionate. Canadian Urological Association Journal, 15(2). https://doi.org/10.5489/cuaj.6651